5,9-Dihydroxy-9-methyl-3,6-dimethylene-decahydroazuleno[4,5-b]furan-2(3H)-one
2011

Study of a Compound from Anvillea radiata

publication Evidence: moderate

Author Information

Author(s): Moumou Mohamed, Benharref Ahmed, Berraho Moha, El Ammari Lahcen, Akssira Mohamed, Elhakmaoui Ahmed

Primary Institution: Laboratoire de Chimie Biomoléculaire, Substances Naturelles et Réactivité, URAC 16, Faculté des Sciences Semlalia, Marrakech, Morocco

Hypothesis

The study investigates the chemical reactivity of 9-hydroxyparthenolide derived from Anvillea radiata.

Conclusion

The study successfully synthesized 5,9-dihydroxy-9-methyl-3,6-dimethylene-decahydro-azulene [4,5-b] furan-2-one with a yield of 45%.

Supporting Evidence

  • The compound was synthesized from 9α-hydroxyparthenolide isolated from Anvillea radiata.
  • The synthesis involved treatment with acids in dichloromethane.
  • The yield of the synthesized compound was 45%.

Takeaway

Researchers made a new chemical compound from a plant called Anvillea radiata, which could be useful in medicine and cosmetics.

Methodology

The compound was synthesized using methane sulfonic acid or p-toluene sulfonic acid in dichloromethane, followed by chromatography for purification.

Digital Object Identifier (DOI)

10.1107/S160053681102352X

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