Ca2+-induced changes in energy metabolism and viability of melanoma cells
1999
Calcium's Effect on Melanoma Cell Energy and Survival
publication
Author Information
Author(s): Glass-Marmor L, Penso J, Beitner R
Primary Institution: Health Sciences Research Center, Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, 52900, Israel
Hypothesis
Does an increase in intracellular calcium ions affect the energy metabolism and viability of melanoma cells?
Conclusion
Increasing calcium levels in melanoma cells can disrupt their energy production and lead to cell death.
Supporting Evidence
- Calcium ionophore A23187 negatively affects glycolysis and viability in melanoma cells.
- Low concentrations of calcium ionophore increase ATP levels initially.
- High concentrations of calcium ionophore lead to a decrease in ATP and cell death.
Takeaway
When calcium levels go up in melanoma cells, it can hurt their ability to make energy and can even kill them.
Methodology
The study used a calcium ionophore to manipulate calcium levels in melanoma cells and measured the effects on glycolysis and cell viability.
Digital Object Identifier (DOI)
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