Time restricted feeding with or without ketosis influences metabolism-related gene expression in a tissue-specific manner in aged rats
2024
Diet and Gene Expression in Aged Rats
publication
Author Information
Author(s): Ding Sarah, Banerjee Anisha, Burke Sara N., Hernandez Abbi R.
Primary Institution: Cold Spring Harbor Laboratory
Hypothesis
How do time-restricted feeding and ketosis affect metabolism-related gene expression in aged rats?
Conclusion
The study found that diet and tissue type significantly influence metabolism-related gene expression and cognitive performance in aged rats.
Supporting Evidence
- TRF-fed rats required less training to learn tasks compared to ad lib fed rats.
- AKT expression was lower in liver and muscle tissue of kTRF fed rats.
- Higher AKT expression in the perirhinal cortex was linked to better cognitive performance in kTRF rats.
- In ad libitum fed rats, higher FOXO1 expression correlated with poorer cognitive performance.
Takeaway
Feeding rats at certain times and with specific diets changes how their bodies work and how well they think.
Methodology
Rats were fed different diets and their gene expression was measured across various tissues.
Participant Demographics
Aged rats (8-25 months old)
Digital Object Identifier (DOI)
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