Aripiprazole for Treating PTSD and Depression in Veterans
Author Information
Author(s): Richardson J Don, Fikretoglu Deniz, Liu Aihua, McIntosh Diane
Primary Institution: St. Joseph's Health Care London - Parkwood Hospital
Hypothesis
Aripiprazole would be efficacious for treatment-resistant military-related PTSD with comorbid major depression.
Conclusion
The addition of aripiprazole contributed to a reduction in both PTSD and depression symptoms in veterans.
Supporting Evidence
- PTSD severity decreased from 56.11 at baseline to 46.85 at 12 weeks.
- Depression severity decreased from 30.44 at baseline to 20.67 at 12 weeks.
- 37% of participants were considered responders for PTSD symptoms.
- 19% of participants were considered responders for depression symptoms.
Takeaway
This study looked at veterans with PTSD and depression and found that adding a medication called aripiprazole helped reduce their symptoms.
Methodology
A retrospective chart review of patients who received a 12-week course of adjunctive aripiprazole.
Limitations
Small sample size, retrospective design, and lack of a control group.
Participant Demographics
Most participants were men (96.3%) with an average age of 39.36 years.
Statistical Information
P-Value
<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website