Link Between Atrial Fibrillation and Glaucoma
Author Information
Author(s): Lee Young, Seo Je Hyun
Primary Institution: Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, Republic of Korea
Hypothesis
Is there a causal relationship between atrial fibrillation/flutter and primary open-angle glaucoma?
Conclusion
The study found a significant causal relationship between atrial fibrillation/flutter and primary open-angle glaucoma.
Supporting Evidence
- Atrial fibrillation/flutter was found to significantly increase the risk of primary open-angle glaucoma.
- The odds ratio for the association was 1.26 with a confidence interval of 1.07 to 1.48.
- Multivariable analysis confirmed the causal association while controlling for other risk factors.
Takeaway
This study suggests that having atrial fibrillation or flutter might increase the risk of developing glaucoma, which is a serious eye condition.
Methodology
A two-sample Mendelian randomisation study was conducted using genetic variants associated with atrial fibrillation/flutter to assess its causal effects on primary open-angle glaucoma.
Potential Biases
The study relied on summary statistics, which limited the ability to account for various confounding factors.
Limitations
The study's findings may not be generalizable to non-European populations, and potential residual confounding factors cannot be ruled out.
Participant Demographics
The study included participants from European cohorts, specifically from Finland and the UK.
Statistical Information
P-Value
0.005
Confidence Interval
1.07–1.48
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website