SUMO4 Polymorphisms and Vogt-Koyanagi-Harada Syndrome in Chinese Han Population
Author Information
Author(s): Hou Shengping, Yang Peizeng, Du Liping, Zhou Hongyan, Lin Xiaomin, Liu Xiaoli, Kijlstra Aize
Primary Institution: The First Affiliated Hospital, Chongqing Medical University
Hypothesis
Are SUMO4 polymorphisms associated with Vogt-Koyanagi-Harada syndrome in the Chinese Han population?
Conclusion
HLA-DR4 and HLA-DRw53 are strongly associated with susceptibility to VKH syndrome, but SUMO4 polymorphisms are not.
Supporting Evidence
- HLA-DR4 and HLA-DRw53 were significantly associated with susceptibility to VKH syndrome.
- A decreased frequency of SUMO4 +438 TT genotype was found in VKH patients compared with healthy controls.
- Stratification analysis did not show any associations between SUMO4 polymorphisms and VKH syndrome.
Takeaway
The study looked at whether certain gene variations are linked to a disease called VKH syndrome in Chinese people, but found that they are not.
Methodology
Genotyping for SUMO4 polymorphisms was performed on 231 VKH patients and 302 controls using PCR-RFLP.
Limitations
The significance of some findings was lost after Bonferroni correction, and the sample size for HLA-DRw53 negative patients was small.
Participant Demographics
231 VKH patients (128 males, 103 females) and 302 healthy controls (164 males, 138 females), all Chinese Han.
Statistical Information
P-Value
p=3.21×10−16
Confidence Interval
95% CI=6.99–26.98
Statistical Significance
p<0.05
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