LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model
2009
LLL-3 Inhibits Glioblastoma Growth
Sample size: 10
publication
Evidence: moderate
Author Information
Author(s): Fuh B, Sobo M, Cen L, Josiah D, Hutzen B, Cisek K, Bhasin D, Regan N, Lin L, Chan C, Caldas H, DeAngelis S, Li C, Li P-K, Lin J
Primary Institution: The Ohio State University
Hypothesis
Can LLL-3 inhibit STAT3 activity and glioblastoma cell growth?
Conclusion
LLL-3 effectively inhibits glioblastoma cell growth and prolongs survival in a mouse model.
Supporting Evidence
- LLL-3 inhibited the viability of glioblastoma cells by more than 90%.
- Treatment with LLL-3 led to increased apoptosis in glioblastoma cells.
- Mice treated with LLL-3 had a median survival of 28.5 days compared to 16 days for control mice.
Takeaway
LLL-3 is a new medicine that helps fight brain cancer by stopping cancer cells from growing and helping mice live longer.
Methodology
The study used cell viability assays, apoptosis detection, and a mouse model to evaluate the effects of LLL-3 on glioblastoma.
Statistical Information
P-Value
0.03
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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