Expression and regulation of transcript for the novel transmembrane protein Tmem182 in the adipocyte and muscle lineage
2008
Study of Tmem182 Protein in Fat and Muscle Cells
Sample size: 10
publication
Evidence: moderate
Author Information
Author(s): Wu Yu, Smas Cynthia M
Primary Institution: University of Toledo, Health Science Campus
Hypothesis
Tmem182 may function in intracellular pathways important in adipocyte and myocyte differentiation.
Conclusion
Tmem182 transcript is primarily expressed in white adipose tissue and its levels are altered in obesity and inflammation.
Supporting Evidence
- Tmem182 transcript is upregulated 45-fold during adipocyte differentiation.
- Highest Tmem182 expression is found in white adipose tissue compared to other tissues.
- Tmem182 levels are altered in genetically obese mice.
- TNFα treatment decreases Tmem182 transcript levels by ~90%.
Takeaway
This study looks at a protein called Tmem182 that is important for fat and muscle cells, showing it works differently when these cells change.
Methodology
Real-time PCR analysis was used to measure Tmem182 transcript levels in various tissues and cell models.
Participant Demographics
Murine tissues and cell lines were used in the study.
Statistical Information
P-Value
p < 0.001
Statistical Significance
p < 0.001
Digital Object Identifier (DOI)
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