Collagen Crosslink Excretion in Oral Cancer Patients
Author Information
Author(s): Springer I N G, Terheyden H, Suhr M A A, Warnke P, Dunsche A, Tiemann M, Açil Y
Primary Institution: University of Kiel
Hypothesis
A successful treatment of patients with OSCC with and without bony infiltration leads to a reduction of urinary HP and LP concentrations toward the normal range, and that ongoing disease might be associated with constant or increasing values.
Conclusion
The study found that urinary concentrations of HP and LP decrease significantly after successful treatment of OSCC, indicating their potential as markers for disease progression.
Supporting Evidence
- The detection of LP in urine can separate patients with OSCC with bone infiltration from those without.
- Urinary HP and LP concentrations were shown to normalize after successful treatment.
- Increased urinary levels of HP and LP are associated with the presence of tumor tissue.
- The study demonstrated a significant decrease in urinary HP and LP concentrations after treatment.
Takeaway
Doctors can check the levels of certain substances in urine to see if cancer treatment is working or if the cancer is coming back.
Methodology
The study analyzed urinary samples from patients with OSCC and compared them to control samples, measuring levels of HP and LP before and after treatment.
Potential Biases
Potential bias in patient selection and exclusion criteria may affect the generalizability of the findings.
Limitations
The study did not include a diverse demographic, focusing primarily on a specific age range and type of cancer.
Participant Demographics
Patients aged 44–88 years, with a mix of genders and varying stages of OSCC.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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