Proanthocyanidins and Oral Cancer
Author Information
Author(s): King Michael, Chatelain Kourt, Farris Dustin, Jensen Dayne, Pickup Jason, Swapp Aaron, O'Malley Susan, Kingsley Karl
Primary Institution: Department of Biomedical Sciences, School of Dental Medicine, University of Nevada, Las Vegas, USA
Hypothesis
PAC modulates, in a dose-dependent manner, the proliferative phenotype of OSCC in vitro.
Conclusion
PAC may be a promising candidate for preventing and treating oral cancer by inhibiting cell proliferation.
Supporting Evidence
- PAC significantly suppressed cellular proliferation of OSCC in a dose-dependent manner.
- PAC administration reduced the proliferation of HPV-positive OSCC.
- PAC induced apoptosis in cervical and oral cancer cell lines.
Takeaway
This study found that a compound from plants called PAC can help slow down the growth of oral cancer cells.
Methodology
In vitro assays were used to measure the effects of PAC on various cancer and non-cancer cell lines.
Limitations
The study was conducted in vitro, and results may not directly translate to in vivo conditions.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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