Impact of Opioid Use and Anesthesia in Prostate Cancer Surgery
Author Information
Author(s): Marcon Julian, Bischoff Robert, Rattenhuber Kaspar, Chaloupka Michael, Askari Darjusch, Jokisch Jan-Friedrich, Becker Armin J., Pfitzinger Paulo L., Keller Patrick, Berg Elena, Stief Christian G., Siegl Daniel, Kowalski Christian, Buchner Alexander, Pyrgidis Nikolaos, Weinhold Philipp, Hollmann Markus W., Kim Won Ho
Primary Institution: Department of Urology, University Hospital of the LMU Munich
Hypothesis
Higher doses of intraoperative opioids may negatively affect long-term oncological outcomes after radical prostatectomy.
Conclusion
Intraoperative opioid application during radical prostatectomy has no negative impact on prognosis in patients with localized prostate cancer.
Supporting Evidence
- 93% of patients received total intravenous anesthesia (TIVA).
- 24% of patients developed biochemical recurrence after a median follow-up of 431 days.
- 2.9% of patients died after a median follow-up of 500 days.
- Type of anesthesia did not affect biochemical recurrence or overall survival.
- Patients receiving higher doses of opioids had similar outcomes compared to those with lower doses.
Takeaway
This study found that using opioids during prostate cancer surgery doesn't seem to harm patients in the long run, no matter how much is used.
Methodology
Patients undergoing radical prostatectomy were analyzed for the impact of intraoperative opioid doses and anesthesia type on biochemical recurrence and survival.
Potential Biases
Potential bias due to uneven distribution of anesthesia types among patients.
Limitations
The study was limited by its single-center design and the exclusion of patients with metastatic prostate cancer.
Participant Demographics
Median age of participants was 66 years, with a significant proportion having locally advanced disease.
Statistical Information
Confidence Interval
95% CI: 0.45 to 1.46
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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