Effects of Differentiation and Proliferation Inducers on Cancer Cell Behavior
Author Information
Author(s): Liu F, Qi H-L, Chen H-L
Primary Institution: Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry, School of Medicine, Fu-Dan University, Shanghai, 200032, China
Hypothesis
How do differentiation and proliferation inducers affect Lewis antigens and metastatic potential in hepatocarcinoma cells?
Conclusion
Differentiation inducers suppress and proliferation inducers promote the metastatic potential of hepatocarcinoma cells.
Supporting Evidence
- 7721 cells mainly expressed sialyl Lewis X and a less amount of sialyl dimeric Lewis X antigens.
- Expressions of SLex antigen were down-regulated by ATRA and up-regulated by EGF.
- Migration and invasion of 7721 cells were reduced by ATRA or 8-Br-cAMP.
Takeaway
Some treatments can make cancer cells less likely to spread, while others can make them more likely to spread.
Methodology
The study used various treatments on the 7721 human hepatocarcinoma cell line and analyzed changes in cell adhesion, migration, and invasion.
Participant Demographics
Human hepatocarcinoma cells
Digital Object Identifier (DOI)
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