TXNIP Regulates Glucose Uptake in Humans
Author Information
Author(s): Parikh Hemang, Carlsson Emma, Chutkow William A, Johansson Lovisa E, Storgaard Heidi, Poulsen Pernille, Saxena Richa, Ladd Christine, Schulze P. Christian, Mazzini Michael J, Jensen Christine Bjørn, Krook Anna, Björnholm Marie, Tornqvist Hans, Zierath Juleen R, Ridderstråle Martin, Altshuler David, Lee Richard T, Vaag Allan, Groop Leif C, Mootha Vamsi K
Primary Institution: Lund University, University Hospital Malmö
Hypothesis
Does TXNIP play a role in regulating glucose uptake in human skeletal muscle?
Conclusion
TXNIP regulates both insulin-dependent and insulin-independent pathways of glucose uptake in human skeletal muscle.
Supporting Evidence
- TXNIP expression is inversely correlated with total body measures of glucose uptake.
- Forced expression of TXNIP in cultured adipocytes significantly reduced glucose uptake.
- Silencing TXNIP in adipocytes and skeletal muscle enhanced glucose uptake.
- TXNIP expression is consistently elevated in the muscle of prediabetics and diabetics.
- TXNIP regulates glucose uptake in insulin-responsive cells.
Takeaway
TXNIP is a protein that helps control how our bodies use sugar, and when it doesn't work right, it can lead to diabetes.
Methodology
The study combined human insulin/glucose clamp physiological studies with genome-wide expression profiling and genetic association studies.
Limitations
No significant association was found between TXNIP genetic variants and type 2 diabetes.
Participant Demographics
The study included 4,450 Scandinavian individuals, including nondiabetic volunteers and twins.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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