G-CSF and SOFA Score for Predicting Mortality in Sepsis Patients
Author Information
Author(s): Fu Xiaomeng, Zhang Ye, Wang Junyu, Liu Yugeng, Wei Bing
Primary Institution: Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
Hypothesis
Can granulocyte colony-stimulating factor (G-CSF) combined with the SOFA score predict mortality in sepsis patients?
Conclusion
G-CSF, SOFA, APACHE II, and SBP are independent predictors of mortality among patients with sepsis, with G-CSF and SOFA showing significant prognostic capability.
Supporting Evidence
- G-CSF levels were significantly higher in non-survivors compared to survivors.
- SOFA and APACHE II scores were identified as independent risk factors for mortality.
- The combination of G-CSF and SOFA improved predictive accuracy for 28-day mortality.
- Logistic regression analysis indicated G-CSF as an independent risk factor for mortality.
- Receiver operating characteristic curve analysis showed G-CSF had a sensitivity of 81.1%.
Takeaway
Doctors can use a blood test for G-CSF and a scoring system called SOFA to help figure out if a patient with sepsis might not survive.
Methodology
The study included 171 sepsis patients, analyzed G-CSF levels, SOFA and APACHE II scores, and used logistic regression and ROC curve analysis.
Potential Biases
Potential bias due to the single-center study design and prior treatments affecting cytokine levels.
Limitations
The study is limited by its single-center design and the measurement of cytokines at only one time point.
Participant Demographics
Patients aged ≥18 with sepsis, including both genders, admitted to the emergency department.
Statistical Information
P-Value
0.017 for G-CSF, <0.001 for SOFA and APACHE II
Confidence Interval
95% CI for G-CSF: 1.000, 1.004; for SOFA: 1.282, 1.923; for APACHE II: 1.062, 1.242
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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