rac-6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxamide from synchrotron data
2011
Crystal Structure of Trolox Amide
publication
Evidence: high
Author Information
Author(s): Krzysztof Brzezinski, Zbigniew Dauter, Aneta Baj, Piotr Wałejko, Stanisław Witkowski
Primary Institution: National Cancer Institute, Argonne National Laboratory
Conclusion
The study successfully solved and refined the crystal structure of trolox amide, revealing its unique molecular arrangement and hydrogen bonding interactions.
Supporting Evidence
- The crystal structure contains two molecules in the asymmetric unit.
- The heterocyclic ring is in a half-chair conformation.
- The crystal packing features a herring-bone pattern generated by hydrogen bonds.
Takeaway
The researchers looked at how a vitamin E-like compound, trolox amide, is structured at a tiny level, showing how its molecules fit together and interact.
Methodology
The crystal structure was solved and refined using synchrotron diffraction data.
Digital Object Identifier (DOI)
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