Dioscin and Diosgenin Help Treat High Altitude Gout by Reducing Kidney Inflammation
Author Information
Author(s): Dang Wanyun, Li Fangyang, Gao Rong, Zhang Cheng, Cheng Hongbo, Wu Zhenhui, Yang Tingyu, Pan Jinchao, Tang Xianglin, Gao Yue, Lymperopoulos Anastasios, Armanini Decio
Primary Institution: Guangdong Pharmaceutical University
Hypothesis
Dioscin and its active metabolite diosgenin can protect the kidneys through anti-inflammation and increase uric acid excretion.
Conclusion
Dioscin and diosgenin can improve kidney function and reduce uric acid levels in rats with plateau hyperuricemia.
Supporting Evidence
- Dioscin reduced uric acid levels in model rats significantly.
- Dioscin improved kidney function indicators such as CREA and BUN.
- Dioscin alleviated kidney damage as observed in histopathological examinations.
- Dioscin decreased levels of pro-inflammatory factors in the kidneys.
- Dioscin increased the expression of the EPHX2 gene in renal tissues.
Takeaway
Dioscin and its metabolite diosgenin can help treat gout caused by high altitude by making the kidneys work better and reducing inflammation.
Methodology
The study used a rat model of high-altitude hyperuricemia and evaluated the effects of dioscin and diosgenin on kidney function and inflammation through biochemical and histopathological analyses.
Limitations
The study was limited by the small sample size of rats used in the hypobaric oxygen chamber.
Participant Demographics
Male Sprague Dawley rats, aged 7-8 weeks.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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