Efficacy and Safety of 5-Loxin® for Osteoarthritis of the Knee
Author Information
Author(s): Sengupta Krishanu, Alluri Krishnaraju V, Satish Andey Rama, Mishra Simanchala, Golakoti Trimurtulu, Sarma Kadainti VS, Dey Dipak, Raychaudhuri Siba P
Primary Institution: Alluri Sitarama Raju Academy of Medical Sciences (ASRAM)
Hypothesis
Does 5-Loxin® improve pain and physical function in patients with osteoarthritis of the knee?
Conclusion
5-Loxin® significantly reduces pain and improves physical functioning in osteoarthritis patients and is safe for human consumption.
Supporting Evidence
- Both doses of 5-Loxin® showed significant improvements in pain and physical function scores.
- Improvements were noted as early as 7 days after starting treatment.
- 5-Loxin® reduced levels of the cartilage degrading enzyme MMP-3 in synovial fluid.
- The safety parameters remained unchanged in the treatment groups compared to placebo.
Takeaway
5-Loxin® is a natural supplement that helps people with knee pain feel better and move easier.
Methodology
A 90-day, double-blind, randomized, placebo-controlled study with 75 osteoarthritis patients receiving either 100 mg or 250 mg of 5-Loxin® or a placebo.
Potential Biases
Potential bias in patient selection and reporting of outcomes.
Limitations
The study was conducted at a single center and had a relatively small sample size.
Participant Demographics
Patients aged 40 years or older with a diagnosis of osteoarthritis.
Statistical Information
P-Value
<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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