Impact of Synthetic Colloids on Organ Function in Severe Sepsis Patients
Author Information
Author(s): Bayer O, Kohl M, Kabisch B, Riedemann N, Sakr Y, Hartog C, Reinhart K
Primary Institution: Friedrich-Schiller-University, Jena, Germany
Hypothesis
What are the effects of synthetic colloids on kidney, liver, and lung function in septic patients compared to crystalloids?
Conclusion
Synthetic colloids may increase the risk of renal failure, impair liver function, and prolong ventilation time in septic patients.
Supporting Evidence
- Patients receiving synthetic colloids had a higher incidence of acute kidney injury compared to those receiving crystalloids.
- Liver enzymes peaked in the synthetic colloid groups but not in the crystalloid group.
- Bilirubin levels were significantly elevated in the synthetic colloid groups over 14 days.
- Ventilation time was significantly longer in the synthetic colloid groups compared to the crystalloid group.
Takeaway
Using certain fluids called synthetic colloids can make sick people with infections have more problems with their kidneys and livers.
Methodology
A prospective controlled before-and-after study comparing synthetic colloids and crystalloids in severe sepsis patients.
Participant Demographics
Patients with severe sepsis, analyzed over a period from 2004 to 2010.
Statistical Information
P-Value
P = 0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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