Detecting Acute Aortic Dissection with Yes-Associated Protein
Author Information
Author(s): Zhu Kai, Li Hao-Xi, Wu Dong-Dong, Qian Si-Chong, Wang Xiao-Long, Li Jian-Rong, Jiang Wen-Jian, Liu Hong, Li Hai-Yang, Zhang Hong-Jia
Primary Institution: Beijing Anzhen Hospital, Capital Medical University, Beijing, China
Hypothesis
The study aims to explore the association between Yes-associated protein (YAP) and the diagnosis and prognosis of acute type A aortic dissection (ATAAD).
Conclusion
Serum YAP concentration is an early and sensitive bioindicator for distinguishing acute aortic dissection from acute coronary syndrome and predicting postoperative major adverse events.
Supporting Evidence
- YAP levels were significantly higher in ATAAD patients compared to ACS patients.
- The optimal cutoff value for YAP in diagnosing ATAAD was found to be 3.15 ng/ml.
- The combined model of YAP, WBC count, and D-Dimer showed enhanced predictive power for ATAAD diagnosis.
- YAP levels at 12 hours post-surgery were predictive of postoperative major adverse events.
Takeaway
Doctors can use a blood test for a protein called YAP to quickly tell if someone has a serious heart problem called aortic dissection, which can help them treat it faster.
Methodology
The study prospectively recruited 110 patients with chest pain, measuring YAP levels and other biomarkers to assess their predictive value for diagnosing ATAAD and postoperative outcomes.
Potential Biases
Potential selection bias due to the single-center design and small sample size.
Limitations
The study was conducted in a single center with a relatively small population size, which may introduce selection bias.
Participant Demographics
Patients aged between 18 and 80 years, with 60 diagnosed with ATAAD and 50 with acute coronary syndrome.
Statistical Information
P-Value
p<0.01
Confidence Interval
95% CI, 0.90–0.98
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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