Selectivity of Inhibition of N-Succinyl-l,l-Diaminopimelic Acid Desuccinylase in Bacteria: The product of dapE-gene Is Not the Target of l-Captopril Antimicrobial Activity
2011
Inhibition of Bacterial Growth by l-Captopril
publication
Evidence: moderate
Author Information
Author(s): Uda Narasimha Rao, Creus Marc
Primary Institution: Department of Chemistry, University of Basel
Hypothesis
Is l-captopril inhibiting DapE in bacteria?
Conclusion
l-Captopril does not primarily target DapE for its antimicrobial activity in bacteria.
Supporting Evidence
- l-Captopril showed modest antimicrobial activity in E. coli and Salmonella enterica.
- Inhibition of bacterial growth was independent of mDAP supplementation.
- DapE over-expression did not affect l-captopril's inhibition of bacterial growth.
Takeaway
The study found that l-captopril, a drug, can stop bacteria from growing, but it doesn't do this by blocking a specific enzyme called DapE.
Methodology
The study tested the effects of l-captopril on bacterial growth in various strains with and without DapE.
Limitations
The study does not explore the specific mechanism of l-captopril's antimicrobial activity.
Digital Object Identifier (DOI)
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