EEG Microstate Analysis in Drug-Naive Patients with Panic Disorder
Author Information
Author(s): Kikuchi Mitsuru, Koenig Thomas, Munesue Toshio, Hanaoka Akira, Strik Werner, Dierks Thomas, Koshino Yoshifumi, Minabe Yoshio
Primary Institution: Kanazawa University, Japan
Hypothesis
Aberrant brain resting state networks in patients with panic disorder must be reflected by deviant EEG microstate properties.
Conclusion
Patients with panic disorder show alterations in specific brain functional states during resting conditions.
Supporting Evidence
- Patients with panic disorder showed longer microstate durations in class A compared to controls.
- Microstates of class C were observed less frequently in patients than in controls.
- Specific brain functions are altered in patients with panic disorder even during resting conditions.
Takeaway
This study looked at brain activity in people with panic disorder and found that their brains behave differently even when they are not feeling anxious.
Methodology
EEG microstates were analyzed in 18 drug-naive patients with panic disorder and 18 healthy controls.
Potential Biases
None reported.
Limitations
Small number of subjects, lack of matching for socioeconomic status, and insufficient clinical assessment scales.
Participant Demographics
18 drug-naive patients (11 men, 7 women) aged 16-52 and 18 healthy controls (11 men, 7 women) aged 20-54.
Statistical Information
P-Value
p=0.035 for class A duration, p=0.015 for class C occurrence, p=0.003 for class A total time.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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