Efficacy of the motile sperm organelle morphology examination (MSOME) in predicting pregnancy after intrauterine insemination

2011

Using MSOME to Predict Pregnancy After Intrauterine Insemination

Sample size: 111 publication 10 minutes Evidence: moderate

Author Information

Author(s): Livia D Akl, Joao Batista Oliveira, Claudia G Petersen, Ana L Mauri, Liliane F I Silva, Fabiana C Massaro, Ricardo L R Baruffi, Mario Cavagna, Jose G Franco Jr

Primary Institution: Center for Human Reproduction Prof. Franco Jr., Ribeirao Preto, Brazil

Hypothesis

The study aims to determine the prognostic value of normal sperm morphology using MSOME with regard to clinical pregnancy after intrauterine insemination.

Conclusion

The findings support the use of high-magnification microscopy for selecting spermatozoa and as a routine method for analyzing semen before performing IUI.

Supporting Evidence

Pregnancy occurred in 34 IUI cycles, with a clinical pregnancy rate of 21.8%.
The percentage of normal spermatozoa was significantly higher in cycles that resulted in pregnancy.
Logistic regression indicated that normal sperm morphology was a determining factor for clinical pregnancy likelihood.
The ROC curve showed an area under the curve of 0.63 for predicting pregnancy based on sperm morphology.
At a cut-off of 2% normal sperm morphology, the sensitivity was 50% and specificity was 79%.

Takeaway

This study looked at how well a special sperm test can predict if a couple will get pregnant after a simple procedure called IUI. It found that better-looking sperm can mean a better chance of having a baby.