Chemokines and Coronary Collaterals
Author Information
Author(s): Keeley Ellen C., Moorman J. Randall, Liu Ling, Gimple Lawrence W., Lipson Lewis C., Ragosta Michael, Taylor Angela M., Lake Douglas E., Burdick Marie D., Mehrad Borna, Strieter Robert M.
Primary Institution: University of Virginia, Charlottesville, Virginia, United States of America
Hypothesis
In patients with chronic ischemic heart disease, a profile of circulating levels of CXC chemokines is associated with the presence and extent of spontaneously visible coronary collaterals.
Conclusion
Plasma chemokine concentrations are associated with the presence and extent of spontaneously visible coronary artery collaterals and may be mechanistically involved in their recruitment.
Supporting Evidence
- 88 out of 156 patients (56%) had evidence of coronary collaterals.
- Higher Rentrop scores were significantly associated with increased concentration of the angiogenic ligand CXCL1.
- The presence of an occluded artery was associated with a higher likelihood of having collaterals.
Takeaway
This study found that certain proteins in the blood, called chemokines, are linked to the presence of small blood vessels that help supply the heart when the main arteries are blocked.
Methodology
Plasma concentrations of angiogenic and angiostatic chemokines were measured in 156 patients undergoing coronary angiography, and the presence and extent of coronary collaterals were assessed using the Rentrop scoring system.
Limitations
The study may have underestimated the presence of collaterals by measuring only spontaneously visible collaterals and may be under-powered to detect significant differences in baseline demographics.
Participant Demographics
Patients were consecutive individuals referred for coronary angiography, all over 21 years old, with at least one ≥90% coronary stenosis.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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