Calcitriol and Heart Function After Heart Attack
Author Information
Author(s): Olędzki Szymon, Siennicka Aldona, Maciejewska-Markiewicz Dominika, Stachowska Ewa, Jakubiak Natalia, Kiedrowicz Radosław, Jakubczyk Karolina, Skonieczna-Żydecka Karolina, Gutowska Izabela, Kaźmierczak Jarosław
Primary Institution: Pomeranian Medical University in Szczecin
Hypothesis
What is the relationship between calcidiol and calcitriol serum concentration and left ventricular ejection fraction early after interventional treatment for acute coronary syndrome?
Conclusion
A low calcitriol serum concentration is associated with more severe heart function issues after a heart attack.
Supporting Evidence
- Only 9% of patients had a proper level of 25-OHD3 in the serum.
- Patients with left ventricle ejection fraction of <40% had significantly lower concentrations of calcidiol and calcitriol.
- A total of 75% of patients had a concentration of 25-OHD3 lower than 20 ng/mL.
- Low calcitriol serum concentration affects post-MI left ventricle ejection fraction early after myocardial infarction onset.
Takeaway
This study found that many heart attack patients have low vitamin D levels, which might make their heart function worse after the attack.
Methodology
The study included 80 myocardial infarction patients who had blood samples taken for vitamin D analysis after primary PCI.
Potential Biases
Potential biases may arise from the exclusion of certain patient demographics and factors not accounted for in the study.
Limitations
The study did not measure several important factors that could influence MI and vitamin D status, such as blood pressure and complete blood count.
Participant Demographics
The study included 80 patients, 22 women and 58 men, diagnosed with myocardial infarction.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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