Preferential regulation of duplicated genes by microRNAs in mammals
2008
MicroRNAs and Duplicated Genes in Mammals
Sample size: 12605
publication
Evidence: high
Author Information
Author(s): Li Jingjing, Musso Gabriel, Zhang Zhaolei
Primary Institution: University of Toronto
Hypothesis
MicroRNAs play a significant role in the regulation of duplicated genes in mammals.
Conclusion
MicroRNAs are crucial for the regulatory evolution of mammalian paralogs, helping to manage gene dosage effects and maintain phenotypic stability.
Supporting Evidence
- MicroRNA targets are significantly enriched for duplicate genes.
- Duplicate genes are more likely to be regulated by multiple microRNA species.
- Ancient duplicates show greater expression divergence and fewer shared microRNA regulators.
Takeaway
MicroRNAs help control how similar genes work together in animals, especially when those genes are copies of each other.
Methodology
The study analyzed microRNA targets in human and mouse genes, comparing duplicated genes to singletons using various prediction methods.
Statistical Information
P-Value
p<5 × 10-89
Statistical Significance
p<5 × 10-89
Digital Object Identifier (DOI)
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