Target Bioconjugation of Protein Through Chemical, Molecular Dynamics, and Artificial Intelligence Approaches
Author Information
Author(s): Abbas Sk Jahir, Yesmin Sabina, Vittala Sandeepa K., Sepay Nayim, Xia Fangfang, Ali Sk Imran, Chang Wei-Chun, Hung Yao-Ching, Ma Wen-Lung
Primary Institution: China Medical University, Taiwan
Hypothesis
Covalent modification of proteins at specific sites is essential for advancing biological and biopharmaceutical applications.
Conclusion
The review highlights the importance of site-selective protein modification techniques and the role of computational methods in enhancing our understanding of protein dynamics.
Supporting Evidence
- Site-selective labeling techniques allow tracking of biological function.
- Computational methods enhance predictions of structural changes in proteins.
- Recent strategies involve traceless affinity labeling and catalyst tethering.
Takeaway
This study talks about how scientists can change proteins in specific ways to help with medicine and biology, using both chemistry and computer technology.
Methodology
The review discusses various chemical and computational methodologies for site-selective protein modification.
Limitations
The review notes that many existing methods have limitations regarding efficiency and specificity.
Digital Object Identifier (DOI)
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