Caffeine Supplement and Liver Health in Cirrhotic Patients
Author Information
Author(s): Seyed Ali Abbas-Hashemi, Zahra Yari, Behzad Hatami, Amir Anushiravani, Shadi Kolahdoozan, Ali Zamanian, Nadia Akbarzadeh, Azita Hekmatdoost
Primary Institution: Shahid Beheshti University of Medical Sciences, Tehran, Iran
Hypothesis
Can caffeine supplementation improve inflammation and liver function in cirrhotic patients?
Conclusion
Daily supplementation of 400 mg caffeine in cirrhotic patients can significantly improve liver fibrosis and reduce inflammatory factors.
Supporting Evidence
- Caffeine supplementation resulted in a significant reduction in inflammatory biomarkers compared to placebo.
- A significant improvement in liver indices including AST to platelet ratio index (APRI) was observed after 8 weeks of caffeine supplementation.
- The compliance of participants was over 85% with no adverse events reported.
Takeaway
Giving cirrhotic patients caffeine can help their liver feel better and reduce inflammation.
Methodology
This was a randomized, double-blind, placebo-controlled trial with 50 cirrhotic patients receiving either caffeine or placebo for eight weeks.
Potential Biases
None reported.
Limitations
The study had a small sample size and short duration.
Participant Demographics
Patients aged 18-75 with cirrhosis induced by viral hepatitis, fatty liver disease, or autoimmune hepatitis.
Statistical Information
P-Value
P<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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