Effect of the chemokine receptor CXCR7 on proliferation of carcinoma cells in vitro and in vivo
2008
CXCR7 and Carcinoma Cell Growth
publication
Evidence: moderate
Author Information
Author(s): Meijer J, Ogink J, Roos E
Primary Institution: The Netherlands Cancer Institute
Hypothesis
Does CXCR7 promote the proliferation of carcinoma cells?
Conclusion
CXCR7 can enhance the proliferation of certain carcinoma cells, but does not affect tumor growth in vivo.
Supporting Evidence
- CXCL12 promotes proliferation of CT26 colon and KEP1 mammary carcinoma cells.
- CXCR7-mediated effects were observed in both CT26 and KEP1 cells.
- Complete suppression of CXCR7 did not affect tumor growth in vivo.
Takeaway
CXCR7 helps some cancer cells grow faster, but it doesn't help tumors grow bigger in living animals.
Methodology
The study involved in vitro and in vivo experiments using various carcinoma cell lines and assessing proliferation and chemotaxis.
Limitations
The study's findings may not apply to all types of carcinomas or in all tumor environments.
Statistical Information
P-Value
<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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