HCV Seropositivity in Family Members of HCV Positive Patients
Author Information
Author(s): La Torre Giuseppe, Miele Luca, Mannocci Alice, Chiaradia Giacomina, Berloco Filippo, Gabrieli Maria L, Gasbarrini Giovanni, Ficarra Maria Giovanna, Matera Antonio, Ricciardi Gualtiero, Grieco Antonio
Primary Institution: Catholic University of the Sacred Heart, School of Medicine 'Agostino Gemelli', Rome, Italy
Hypothesis
What are the correlates of HCV seropositivity among familial contacts of HCV positive patients?
Conclusion
Having intercourse with a drug addict is the most significant risk factor for intrafamilial HCV transmission.
Supporting Evidence
- 8.9% of family contacts tested positive for HCV.
- Intercourse with drug addicts was significantly associated with HCV positivity.
- Retirement status was also linked to higher HCV seropositivity.
- Tattoos were identified as a potential risk factor for HCV transmission.
Takeaway
This study found that family members of people with hepatitis C can also get the virus, especially if they have close contact with drug users.
Methodology
A cross-sectional study with 175 HCV positive patients and 259 familial contacts, using questionnaires and blood tests to assess HCV infection.
Potential Biases
Potential information bias due to reliance on self-reported data.
Limitations
The study is cross-sectional, making it difficult to establish cause-and-effect relationships.
Participant Demographics
175 HCV positive patients (40% female, mean age 57) and 259 family contacts (155 females, 104 males, mean age 40.4).
Statistical Information
P-Value
0.004 for intravenous drug addiction, 0.005 for intercourse with drug addicts.
Confidence Interval
95% CI: 2.01 – 184.94 for intercourse with drug addicts.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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