Cord Clamping in Preterm Infants: A Study on Survival Outcomes
Author Information
Author(s): Knol Ronny, Brouwer Emma, van den Akker Thomas, DeKoninck Philip L.J., Onland Wes, Vermeulen Marijn J., de Boode Willem P., van Kaam Anton H., Lopriore Enrico, Reiss Irwin K.M., Hutten G. Jeroen, Prins Sandra A., Mulder Estelle E.M., d’Haens Esther J., Hulzebos Christian V., Bouma Helene A., van Sambeeck Sam J., Niemarkt Hendrik J., van der Putten Mayke E., Lebon Tinta, Zonnenberg Inge A., Nuytemans Debbie H., Willemsen Sten P., Polglase Graeme R., Steggerda Sylke J., Hooper Stuart B., te Pas Arjan B.
Primary Institution: Erasmus MC University Medical Center Rotterdam
Hypothesis
Does physiological-based cord clamping improve survival without major cerebral injury or necrotizing enterocolitis in very preterm infants compared to time-based cord clamping?
Conclusion
Physiological-based cord clamping did not increase survival without major cerebral injury or necrotizing enterocolitis compared to time-based cord clamping in very preterm infants.
Supporting Evidence
- Intact survival occurred in 71.1% of infants after PBCC compared to 67.6% after TBCC.
- PBCC resulted in fewer red blood cell transfusions.
- Lower incidence of late-onset sepsis was observed after PBCC.
Takeaway
This study looked at how long to wait before cutting the cord for very premature babies. It found that waiting longer didn't help them survive better, but it did make parents feel less anxious.
Methodology
A multicentre, randomised controlled trial comparing physiological-based cord clamping with time-based cord clamping in very preterm infants.
Potential Biases
Potential selection bias due to antenatal consent and the learning curve associated with the new procedure.
Limitations
The study included only infants after antenatal consent, which may limit generalizability, and not all allocated infants received the intended procedure.
Participant Demographics
Infants born before 30 weeks of gestation, median gestational age 27+5 weeks.
Statistical Information
P-Value
0.33
Confidence Interval
95% CI 0.84–1.66
Statistical Significance
p=0.33
Digital Object Identifier (DOI)
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