Estrogen receptor beta expression in prostate adenocarcinoma
2011
Estrogen Receptor Beta in Prostate Cancer
Sample size: 52
publication
Evidence: moderate
Author Information
Author(s): Asgari Mojgan, Morakabati Arman
Primary Institution: Tehran University of Medical Sciences
Hypothesis
The study investigates the expression of estrogen receptor beta (ER-b) in human prostate cancer tissues.
Conclusion
ER-b expression is reduced in high grade prostate cancers compared to low & intermediate grade ones.
Supporting Evidence
- ER-b expression was seen in 100% of low and intermediate grade tumors.
- 83% of high grade tumors expressed ER-b.
- The mean rate of ER-b expression was 68.41% in low & intermediate grade cancers.
Takeaway
This study found that lower grade prostate cancers have more of a protein called ER-b than higher grade cancers.
Methodology
Immunohistochemical staining of prostate needle biopsy samples was performed to assess ER-b expression.
Limitations
The small size of the biopsy specimens may miss focal small lesions.
Participant Demographics
Mean age of patients was 67 years, with a range from 55 to 84 years.
Statistical Information
P-Value
0.027
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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