Generation of angiostatin-like fragments from plasminogen by prostate-specific antigen
1999
Prostate-Specific Antigen Creates Angiostatin-Like Fragments
publication
Author Information
Author(s): Heidtmann H-H, Nettelbeck D M, Mingels A, Jäger R, Welker H-G, Kontermann R E
Primary Institution: St Joseph Hospital, Bremerhaven, Germany
Hypothesis
Can prostate-specific antigen convert plasminogen into angiostatin-like fragments?
Conclusion
Prostate-specific antigen can generate angiostatin-like fragments from plasminogen that inhibit the growth of endothelial cells.
Supporting Evidence
- Angiostatin is a fragment of plasminogen that inhibits angiogenesis.
- Prostate-specific antigen can convert plasminogen to angiostatin-like fragments.
- The generated fragments inhibit the proliferation of endothelial cells.
Takeaway
A protein from the prostate can turn another protein into a form that stops blood vessel growth, which might help us understand prostate cancer better.
Methodology
In vitro assays were used to test the effects of the generated fragments on endothelial cell proliferation and tubular formation.
Digital Object Identifier (DOI)
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