Expression of inducible nitric oxide synthase in healthy pleura and in malignant mesothelioma
2000
Study of iNOS Expression in Mesothelioma and Pleural Tissues
Sample size: 63
publication
Evidence: moderate
Author Information
Author(s): Soini Y, Kahlos K, Puhakka A, Lakari E, Säily M, Pääkkö P, Kinnula V
Primary Institution: University of Oulu and Oulu University Hospital
Hypothesis
The study investigates the expression of inducible nitric oxide synthase (iNOS) in normal and malignant pleural tissues.
Conclusion
Malignant mesotheliomas and metastatic pleural adenocarcinomas show a high expression of iNOS, suggesting its role in tumor growth and progression.
Supporting Evidence
- 74% of malignant mesotheliomas expressed iNOS.
- 96% of metastatic pleural adenocarcinomas expressed iNOS.
- Epithelial mesotheliomas showed stronger iNOS expression than sarcomatoid subtypes.
Takeaway
The study found that a lot of cancer cells in the pleura make a special protein called iNOS, which might help them grow.
Methodology
The study used immunohistochemistry to assess iNOS expression and the TUNEL method for apoptosis in various tissue samples.
Statistical Information
P-Value
p=0.021, p=0.023
Statistical Significance
p=0.021, p=0.023
Digital Object Identifier (DOI)
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