Immune Cells and Depression in Older Adults
Author Information
Author(s): Iyer Sandhya, Cao Yumeng, Lunetta Kathryn, Liebegott Ryan, Doyle Margaret, Chen Jiachen, Ragab Ahmed, Murabito Joanne
Primary Institution: Boston University School of Medicine
Hypothesis
This study investigates the associations between immune cell phenotypes and inflammatory biomarkers with depressive symptoms.
Conclusion
The study found positive associations between certain immune markers and depressive symptoms in older adults.
Supporting Evidence
- The study found a positive association between FGF-19 and CES-D score.
- There was a suggestive negative trend between the CD8+IL17+:CD8+CD25+FoxP3+ ratio and CES-D score.
- A positive suggestive trend was observed between IL-17C and depressive symptoms.
Takeaway
Researchers looked at how immune cells might be linked to feelings of depression in older people, finding some interesting connections.
Methodology
The study used flow cytometry to determine immune cell phenotypes and measured inflammatory biomarkers with the OLINK Inflammation panel, analyzing data with a linear mixed-effects model.
Participant Demographics
Participants had a mean age of 62, were 52% female, and had a mean CES-D score of 5.
Statistical Information
P-Value
0.0004
Statistical Significance
p<0.005
Digital Object Identifier (DOI)
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