Crosstalk between the EGFR and other signalling pathways at the level of the global transcriptional corepressor Groucho/TLE
2006
Groucho's Role in Signaling Pathways
publication
Evidence: moderate
Author Information
Author(s): Hasson P, Paroush Z
Hypothesis
How does Groucho/TLE interact with EGFR and Notch signaling pathways?
Conclusion
EGFR signaling reduces Groucho's ability to repress gene expression, allowing for the activation of genes involved in cell fate determination.
Supporting Evidence
- Groucho is a corepressor that integrates signals from multiple pathways.
- EGFR signaling can reduce Groucho's repressive effects on gene expression.
- The interaction between EGFR and Notch pathways is mediated by Groucho.
Takeaway
Groucho is like a switch that can turn off certain genes, but when a signal from EGFR comes in, it helps turn those genes back on.
Methodology
This minireview discusses the roles of Groucho in various signaling pathways based on existing literature.
Limitations
The review does not provide new experimental data but synthesizes existing findings.
Digital Object Identifier (DOI)
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