Cholecystokinin and Dietary Fat in Pancreatic Cancer in Rats
Author Information
Author(s): M.J. Appel, M. Meijers, A. Van Garderen-Hoetmer, C.B.H.W. Lamers, L.C. Rovati, D. Sprij-Mooij, J.B.M.J. Jansen, R.A. Woutersen
Primary Institution: TNO Toxicology and Nutrition Institute
Hypothesis
Is dietary fat-promoted pancreatic carcinogenesis mediated by cholecystokinin?
Conclusion
Cholecystokinin enhances pancreatic carcinogenesis in rats, but dietary fat's promoting effect is likely not mediated by cholecystokinin.
Supporting Evidence
- Cholecystokinin increased pancreatic weight in treated rats.
- Rats on a high-fat diet developed more adenomas and adenocarcinomas than those on a low-fat diet.
- Lorglumide inhibited the effect of cholecystokinin on pancreatic carcinogenesis.
Takeaway
This study found that a hormone called cholecystokinin can make pancreatic cancer worse in rats, but eating a lot of fat does this in a different way.
Methodology
240 male weanling SPF Wistar rats were treated with azaserine and fed either a high or low fat diet, with some groups receiving cholecystokinin or its antagonist lorglumide.
Limitations
The study's dietary regimen may have affected body weight gain, which could confound results.
Participant Demographics
240 male weanling SPF Wistar rats
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
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