Circulating Apoptotic Progenitor Cells in Patients with Congestive Heart Failure
Author Information
Author(s): Geft Dael Schwartzenberg, Shmuel Rogowsky, Ori Finkelstein, Ariel Ablin, Jacob Maysel-Auslender, Sofia Wexler, Dov Keren, Gad George Jacob
Primary Institution: Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Hypothesis
We sought to quantify the numbers of apoptotic progenitors in patients with congestive heart failure.
Conclusion
Severe heart failure patients exhibited higher numbers of late apoptotic progenitors, which were positively associated with NYHA class and negatively correlated with ejection fraction.
Supporting Evidence
- There was no significant difference in total CD34 positive cells or early apoptotic progenitors between control subjects and CHF patients.
- Late apoptotic progenitors were significantly increased in CHF patients compared to matched controls.
- An inverse correlation was found between late apoptotic progenitors and ejection fraction.
Takeaway
This study found that patients with severe heart failure have more dying cells that could affect their health, and these cells are linked to how bad their heart condition is.
Methodology
Peripheral blood mononuclear cells were isolated from patients and controls, and apoptosis in progenitor CD34+ cells was assessed using flow cytometry.
Limitations
The study is limited by the relatively small sample size.
Participant Demographics
58 patients with heart failure (median age 76.5) and 23 matched controls (median age 74).
Statistical Information
P-Value
p=0.03 for late apoptotic progenitors between severe and mild/moderate CHF groups.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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