H19 and IGF-2 allele-specific expression in hepatoblastoma
2000
H19 and IGF-2 Expression in Liver Cancer in Children
Sample size: 30
publication
Author Information
Author(s): Ross J A, Radloff G A, Davies S M
Primary Institution: University of Minnesota Cancer Center
Hypothesis
The study investigates the patterns of allele-specific expression of H19 and IGF-2 in hepatoblastoma.
Conclusion
The study found that all informative tumors showed monoallelic expression of H19, while IGF-2 expression varied with the age of the children.
Supporting Evidence
- All informative tumors demonstrated monoallelic expression of H19.
- Variable patterns of allele-specific expression of IGF-2 were seen in tumors from children of different ages.
Takeaway
The researchers looked at how two genes behave in liver cancer in kids, finding one gene always acted the same way, while the other acted differently depending on how old the kids were.
Methodology
Patterns of allele-specific expression were examined in tissue from children diagnosed with hepatoblastoma.
Participant Demographics
Children diagnosed with hepatoblastoma.
Digital Object Identifier (DOI)
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