Stability of Metronidazole in Chicken Eggs
Author Information
Author(s): Vokuev Mikhail, Melekhin Artem, Frolova Anastasia, Bairov Anton, Rodin Igor, Tishchenko Victor
Primary Institution: Lomonosov Moscow State University
Hypothesis
How do storage conditions affect the stability of metronidazole and its metabolite in chicken eggs?
Conclusion
Metronidazole and its metabolite remain stable in chicken eggs stored at -20°C for three months, while significant degradation occurs at 4°C.
Supporting Evidence
- Metronidazole levels decreased by an average of 60% after one month at 4°C.
- At -20°C, metronidazole levels remained stable for three months.
- Hydroxymetronidazole levels dropped by 75% after one month at 4°C.
- Both analytes were present in eggs collected on the 11th day after administration.
Takeaway
This study shows that if you keep chicken eggs in the freezer, the medicine inside them stays good for a long time, but if you put them in the fridge, it goes bad quickly.
Methodology
The study used HPLC-MS/MS to analyze metronidazole and its metabolite in eggs stored at different temperatures over three months.
Limitations
The study focused only on two storage temperatures and did not explore other potential factors affecting drug stability.
Participant Demographics
Five healthy laying hens were used for the study.
Digital Object Identifier (DOI)
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