Clinical outcomes and anti-inflammatory mechanisms predict maximum heart rate improvement after physical activity training in individuals with psychiatric disorders and comorbid obesity
2025

Heart Rate Improvement After Exercise in People with Mental Disorders and Obesity

Sample size: 29 publication 10 minutes Evidence: moderate

Author Information

Author(s): Soldevila-Matías Pau, Sánchez-Ortí Joan Vicent, Correa-Ghisays Patricia, Balanzá-Martínez Vicent, Selva-Vera Gabriel, Sanchis-Sanchis Roberto, Iglesias-García Néstor, Monfort-Pañego Manuel, Tomás-Martínez Pilar, Victor Víctor M., Crespo-Facorro Benedicto, Valenzuela Constanza San Martin, Climent-Sánchez José Antonio, Corral-Márquez Rosana, Fuentes-Durá Inmaculada, Tabarés-Seisdedos Rafael

Primary Institution: University of Valencia, Valencia, Spain

Hypothesis

Can clinical outcomes and inflammatory mechanisms predict heart rate improvement after physical activity training in individuals with psychiatric disorders and obesity?

Conclusion

Regulating anti-inflammatory mechanisms is crucial for maintaining healthy physical activity in individuals with psychiatric disorders and obesity.

Supporting Evidence

  • Participants showed significant improvement in cognition and mood symptoms after the exercise program.
  • Anti-inflammatory activity increased, and cardiovascular mechanisms improved following physical activity training.
  • Better clinical outcomes were critical for predicting significant maximum heart rate variation over time.

Takeaway

This study shows that exercise can help people with mental health issues and obesity feel better and improve their heart health.

Methodology

Participants with psychiatric disorders and obesity underwent a 12-week structured exercise program, with assessments of clinical outcomes and biomarkers before and after the intervention.

Potential Biases

Potential biases include ascertainment, disease classification, and sample selection bias.

Limitations

The sample size was small and limited to individuals with psychiatric disorders and obesity, which may affect generalizability.

Participant Demographics

The sample consisted of 29 individuals with psychiatric disorders, including schizophrenia, bipolar disorder, and major depressive disorder, with a mean age of 47.3 years.

Statistical Information

P-Value

p<0.0001

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1371/journal.pone.0313759

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