Epigenetic Regulation by Lysine Demethylase 5 (KDM5) Enzymes in Cancer
Author Information
Author(s): Blair Lauren P., Cao Jian, Zou Mike Ran, Sayegh Joyce Yan, Qin
Primary Institution: Yale University School of Medicine
Hypothesis
Inhibition of specific enzymes that regulate epigenetic marks would have antitumor effects.
Conclusion
Inhibition of KDM5 enzymes can suppress tumorigenesis and may provide a rationale for developing their inhibitors for cancer therapy.
Supporting Evidence
- Epigenetic changes are reversible, raising the possibility that inhibition of specific enzymes would have antitumor effects.
- Histone demethylases could serve as oncoproteins or tumor suppressors due to their ability to sculpt the histone methylation landscape.
- Genome-wide analyses suggest that genes important for developmental control are marked by 'bivalent marks', which could lead to cancer initiation and progression.
Takeaway
Some proteins in our cells help control how genes are turned on or off. This study looks at how certain proteins, called KDM5 enzymes, can help cancer grow and how stopping them might help treat cancer.
Methodology
This review summarizes current knowledge on the KDM5/JARID1 family of histone demethylases and their roles in cancer.
Limitations
The review does not provide original experimental data but summarizes existing literature.
Digital Object Identifier (DOI)
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