Safety of Omega-3 Fatty Acids in Elderly with Memory Complaints
Author Information
Author(s): Vakhapova Veronika, Richter Yael, Cohen Tzafra, Herzog Yael, Korczyn Amos D
Primary Institution: Tel-Aviv Sourasky Medical Center
Hypothesis
The study evaluates the safety profile of a novel phosphatidylserine preparation with omega-3 fatty acids in non-demented elderly individuals with memory complaints.
Conclusion
Consumption of PS-DHA is safe and well tolerated, showing no negative effects on the tested safety parameters.
Supporting Evidence
- 131 participants completed the double-blind phase with no significant safety differences between groups.
- 121 participants continued into the open-label phase, showing a reduction in resting diastolic blood pressure.
- The treatment was well tolerated with gastrointestinal discomfort being the most common mild symptom.
Takeaway
Older people with memory issues can safely take a new supplement made from fish oil without getting sick.
Methodology
157 non-demented elderly participants were randomized to receive either PS-DHA or placebo for 15 weeks, followed by an open-label extension for 15 weeks.
Potential Biases
Potential bias due to funding from Enzymotec Ltd, the manufacturer of the PS-DHA supplement.
Limitations
The study did not assess long-term effects beyond 30 weeks and relied on self-reported adverse events.
Participant Demographics
Non-demented elderly individuals aged 50 to 90 with memory complaints.
Digital Object Identifier (DOI)
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