Anticonvulsant and neurotoxicity profile of the rhizome of Smilax china Linn. in mice
2011
Anticonvulsant Effects of Smilax china in Mice
Sample size: 6
publication
Evidence: moderate
Author Information
Author(s): Vijayalakshmi A., Ravichandiran V., Anbu J., Velraj Malarkodi, Jayakumari S.
Primary Institution: Vels University
Hypothesis
The study aims to evaluate the anticonvulsant activity and neurotoxicity of the ethanolic extract and ethyl acetate fraction of Smilax china in mice.
Conclusion
The EESC and EAF may help to control petit mal and grand mal seizures.
Supporting Evidence
- The ethanolic extract significantly reduced the duration of hindleg extension in the MES test.
- All test groups prolonged seizure latency in the PTZ model.
- Both EESC and EAF showed significant effects at higher doses.
Takeaway
This study tested a plant extract to see if it can help stop seizures in mice, and it found that it works pretty well.
Methodology
The study involved testing the anticonvulsant activities of ethanolic extract and ethyl acetate fraction against induced seizures in mice using various models.
Participant Demographics
Mice were used in the study.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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