Association of a gene variant with obesity in Balinese
Author Information
Author(s): Malik Safarina G, Saraswati Made R, Suastika Ketut, Trimarsanto Hidayat, Oktavianthi Sukma, Sudoyo Herawati
Primary Institution: Eijkman Institute for Molecular Biology
Hypothesis
Is the ADRB3 Trp64Arg gene polymorphism associated with obesity and metabolic syndrome in Balinese populations?
Conclusion
Urban Balinese have a significantly higher prevalence of obesity and metabolic syndrome compared to rural Balinese, with the Arg64 allele of the ADRB3 gene associated with obesity in rural females.
Supporting Evidence
- Urban Balinese had a higher prevalence of obesity (51%) compared to rural Balinese (24%).
- Abdominal obesity was significantly higher in urban Balinese (62%) than in rural Balinese (36%).
- The Arg64 allele was associated with higher BMI and waist circumference in rural female participants.
Takeaway
This study found that people living in urban areas of Bali are more likely to be overweight or have health problems related to obesity than those in rural areas, and a specific gene variant seems to affect rural women more.
Methodology
A cross-sectional study was conducted with 528 participants from urban and rural Balinese, measuring BMI, waist circumference, and various metabolic parameters.
Potential Biases
Potential bias due to the urban population being exposed to westernization and lifestyle changes.
Limitations
The study had a small sample size and low minor allele frequency, which may reduce the statistical power.
Participant Demographics
Participants included 282 urban and 246 rural Balinese, with a mix of males and females.
Statistical Information
P-Value
p < 0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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