Anti-inflammatory Effects of Plumeria acuminata Leaves
Author Information
Author(s): Gupta M, Mazumder UK, Gomathi P, Selvan V Thamil
Primary Institution: Jadavpur University, Kolkata, West Bengal, India
Hypothesis
The study aims to evaluate the anti-inflammatory activity of methanol extract of leaves of Plumeria acuminata.
Conclusion
The methanol extract of Plumeria acuminata shows significant anti-inflammatory activity in both acute and chronic inflammation models.
Supporting Evidence
- The extract at 500 mg/kg showed maximum anti-inflammatory effects of 30.51%, 47.06%, 34.48%, and 32.50% in different inflammation models.
- MEPA significantly reduced granuloma tissue formation compared to control.
- The study established the LD50 of MEPA to be higher than 2.0 g/kg.
Takeaway
This study found that a plant called Plumeria acuminata can help reduce swelling and inflammation in rats.
Methodology
The study used acute and chronic inflammation models in Wistar albino rats to test the anti-inflammatory effects of the methanol extract.
Limitations
The study was conducted only on animal models, and the effects in humans are not yet established.
Participant Demographics
Wistar albino rats of either sex weighing 180–200 g were used.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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