Detection of p73 antibodies in patients with various types of cancer: immunological characterization
2001
Detection of p73 Antibodies in Cancer Patients
Sample size: 148
publication
Evidence: moderate
Author Information
Author(s): Tominaga O, Unsal K, Zalcman G, Soussi T
Primary Institution: Institut Curie
Hypothesis
The study investigates the immune response towards p73 and p63 proteins in cancer patients.
Conclusion
The study found a specific immune response towards the p73 protein in cancer patients.
Supporting Evidence
- p73 antibodies were detected in 14.9% of cancer patients tested.
- Only 4% of the control group tested positive for p73 antibodies.
- p63 antibodies were detected in only 2.7% of cancer patients.
Takeaway
Doctors looked for special proteins in the blood of cancer patients to see if their bodies were fighting the cancer. They found that many had a response to one of the proteins called p73.
Methodology
Serum samples from 148 cancer patients were tested for antibodies against p73 and p63 using immunoprecipitation.
Participant Demographics
148 patients with various types of cancer and a control group of 50 blood donors.
Digital Object Identifier (DOI)
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