Prognostic value of PTK6 in breast cancer
Author Information
Author(s): Aubele M, Walch A K, Ludyga N, Braselmann H, Atkinson M J, Luber B, Auer G, Tapio S, Cooke T, Bartlett J M S
Primary Institution: Helmholtz Centre Munich, German Research Centre for Environmental Health
Hypothesis
Does PTK6 expression correlate with long-term survival in breast cancer patients?
Conclusion
PTK6 expression is a significant prognostic marker for disease-free survival in breast cancer patients.
Supporting Evidence
- PTK6 expression was found in approximately two-thirds of primary breast tumors.
- High PTK6 expression correlated with disease-free survival of patients over 240 months.
- PTK6 expression was inversely associated with nodal status and tumor size.
Takeaway
This study found that a protein called PTK6 can help predict how long breast cancer patients will live without their cancer coming back.
Methodology
The study used immunohistochemistry on archival breast cancer samples to analyze PTK6 expression and its correlation with patient outcomes.
Potential Biases
Potential selection bias due to the retrospective nature of the study.
Limitations
The study is retrospective and relies on archival samples, which may not represent current treatment practices.
Participant Demographics
The study included 426 patients with invasive breast carcinomas, with a median follow-up of 80 months.
Statistical Information
P-Value
p≤0.001
Statistical Significance
p≤0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website