Topical 5-Fluorouracil 0.5% for Ocular Surface Squamous Neoplasia
Author Information
Author(s): Teixeira Gabriela Carneiro, de Resende Mateus Inacio Lemes, Morales Melina Correia, Fernandes Arthur Gustavo
Primary Institution: Federal University of São Paulo
Hypothesis
Is topical treatment with 5-Fluorouracil 0.5% effective for Ocular Surface Squamous Neoplasia?
Conclusion
Topical 5-FU 0.5% is an effective treatment for OSSN, achieving an 80% success rate with good tolerability.
Supporting Evidence
- 80% of patients achieved therapeutic success after treatment.
- Lesion size affects treatment success, with larger lesions having lower odds of success.
- Only mild adverse effects were reported, with no patients needing to stop treatment.
Takeaway
This study shows that a special eye drop can help treat a type of eye tumor in most patients without making them feel too bad.
Methodology
Patients with OSSN were treated with topical 5-FU 0.5% four times daily for 10 days, followed by a 3-week break, up to 3 cycles.
Potential Biases
Potential bias due to patient adherence assessment.
Limitations
Sample size is small, lacks a control group, and no long-term follow-up.
Participant Demographics
30 patients, 22 males and 8 females, mean age 69.08 years.
Statistical Information
P-Value
0.033
Confidence Interval
95% CI: 60.75–91.18%
Statistical Significance
p=0.033
Digital Object Identifier (DOI)
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