Plant-Derived Morphinan Active Against Malaria Liver Stages
Author Information
Author(s): Carraz Maëlle, Jossang Akino, Franetich Jean-François, Siau Anthony, Ciceron Liliane, Hannoun Laurent, Sauerwein Robert, Frappier François, Rasoanaivo Philippe, Snounou Georges, Mazier Dominique
Primary Institution: Laboratoire de Chimie et Biochimie des Substances Naturelles, Muséum National d'Histoire Naturelle, Paris, France
Hypothesis
The traditional remedy from Strychnopsis thouarsii might contain agents active against the liver stages of malaria.
Conclusion
Tazopsine, a compound derived from a plant, is specifically active against the liver stages of malaria parasites.
Supporting Evidence
- Tazopsine was isolated from a plant used traditionally against malaria.
- It showed significant inhibitory activity against liver stage malaria parasites in vitro.
- NCP-tazopsine, a derivative, had lower toxicity and higher therapeutic index.
- Oral administration of NCP-tazopsine protected mice from malaria infection.
Takeaway
Researchers found a new medicine from a plant that can stop malaria from growing in the liver, which is important for preventing the disease.
Methodology
The study involved isolating a compound from a plant and testing its effects on malaria parasites in lab cultures and mice.
Limitations
The study primarily focused on in vitro and animal models, and further research is needed to evaluate human efficacy.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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