Tachykinin Receptors Antagonism for Asthma: A Systematic Review
Author Information
Author(s): Ramalho Renata, Soares Raquel, Couto Nuno, Moreira André
Primary Institution: Department of Immunology, Faculty of Medicine, University of Porto, Porto, Portugal
Hypothesis
Can tachykinin receptor antagonists improve asthma symptoms and lung function?
Conclusion
The limited available evidence suggests that tachykinin receptors antagonists may decrease airway responsiveness and improve lung function in patients with asthma.
Supporting Evidence
- Five of the seven studies reported a decrease in airway responsiveness with the use of tachykinin receptor antagonists.
- Four studies reported lung function as an outcome, with mixed results.
- Only one study reported airway inflammation as an outcome, showing no improvement.
Takeaway
This study looked at whether certain medications can help people with asthma breathe better. It found that these medications might help with some breathing problems but not with all asthma symptoms.
Methodology
This systematic review examined randomized controlled trials evaluating the effect of tachykinin receptor antagonism on asthma outcomes.
Potential Biases
The methodological quality of the included trials was graded as very low.
Limitations
The review was limited by the small number of studies, varying interventions, and inadequate dosing in many studies.
Participant Demographics
The studies included 98 young adults, with 24 females and 74 males.
Statistical Information
P-Value
<0.05
Confidence Interval
0.841-1.616
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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